Endocrine Abstracts

The endogenous thyroid hormone derivative 3-iodothyronamine (T1AM), and its metabolite 3-iodothyroacetic acid (TA1) are known to stimulate learning and induce hyperalgesia in mice. Recently, it has been demonstrated that exogenous T1AM is able to rescue synaptic impairment after transient ischemia in the entorhinal cortex (EC), a brain area crucially involved in learning and memory, and early affected during Alzheimer’s disease. However, i...

Please Development and preliminary characterization of a simple human thyroid organoid in vitro model for thyroid metabolism investigation For decades, in vitro studies of the thyroid have relied on thyroid-derived tumor cell lines, which are limited by their undifferentiated phenotype, lack of response to TSH, and chromosomal abnormalities. A viable alternative are monolayer (2D) cultures of primary thyrocytes isolated from histologically normal thyroid glan...

Adult-onset hypothyroidism is associated with cognitive dysfunction, and a significant fraction of hypothyroid patients still shows persistent disturbances despite standard T4 replacement therapy. Experimental results showed that tissue levels of T4 metabolites, particularly T1AM, are decreased in hypothyroidism and remain low after T4 replacement. Thyroid hormones are important for the promotion of neurogenesis and neuron migration to different areas of the cerebral cortex, i...